/* Layout: slim control bar, search band, then a dossier grid — identity card on top, two columns of evidence, papers full width. */
:root {
  --bg: #f2f5f4;
  --surface: #ffffff;
  --surface-2: #e8eeec;
  --fg: #13211f;
  --muted: #55665f;
  --line: #d3ddd9;
  --accent: #0a7466;
  --accent-soft: #d7ece8;
  --warm: #b8600e;
  --warm-soft: #f6e6d4;
  --danger: #b3261e;
  /* ClinVar diverging scale: pathogenic (warm) · uncertain (neutral) · benign (cool). Validated for CVD separation. */
  --cv-p: #a3261b; --cv-lp: #e2866a; --cv-vus: #c5cbc9; --cv-lb: #4fab99; --cv-b: #17675b;
  /* AlphaFold pLDDT bands, the convention used across AlphaFold DB. */
  --af-vh: #0053d6; --af-h: #65cbf3; --af-l: #ffdb13; --af-vl: #ff7d45;
  --font-display: "Unbounded", "Segoe UI", system-ui, sans-serif;
  --font-body: "IBM Plex Sans", "Segoe UI", system-ui, -apple-system, sans-serif;
  --font-mono: "IBM Plex Mono", ui-monospace, "Cascadia Mono", Consolas, monospace;
  --radius: 10px;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0d1514; --surface: #142120; --surface-2: #1b2b29; --fg: #e2ecea; --muted: #93a8a2;
    --line: #263936; --accent: #4cc7b3; --accent-soft: #173a35; --warm: #e8a35c; --warm-soft: #3a2a19;
    --danger: #f2a49e; color-scheme: dark;
    --cv-p: #f29384; --cv-lp: #b8574a; --cv-vus: #414d4a; --cv-lb: #2a9a87; --cv-b: #7fd6c6;
  }
}
:root[data-theme="dark"] {
  --bg: #0d1514; --surface: #142120; --surface-2: #1b2b29; --fg: #e2ecea; --muted: #93a8a2;
  --line: #263936; --accent: #4cc7b3; --accent-soft: #173a35; --warm: #e8a35c; --warm-soft: #3a2a19;
  --danger: #f2a49e; color-scheme: dark;
  --cv-p: #f29384; --cv-lp: #b8574a; --cv-vus: #414d4a; --cv-lb: #2a9a87; --cv-b: #7fd6c6;
}
* { box-sizing: border-box; }
html, body { margin: 0; }
body {
  background: var(--bg); color: var(--fg);
  font: 15px/1.55 var(--font-body);
  -webkit-font-smoothing: antialiased;
}
a { color: var(--accent); text-underline-offset: 2px; }
a:hover { text-decoration-thickness: 2px; }
:focus-visible { outline: 2px solid var(--accent); outline-offset: 2px; border-radius: 4px; }
.wrap {
  max-width: 1120px; margin: 0 auto;
  padding-left: max(16px, env(safe-area-inset-left, 0px));
  padding-right: max(16px, env(safe-area-inset-right, 0px));
}

/* Top bar */
.bar { border-bottom: 1px solid var(--line); background: var(--surface); }
.bar .wrap { display: flex; flex-wrap: wrap; align-items: center; gap: 12px 20px; padding-block: 12px; }
.brand { display: flex; align-items: baseline; gap: 10px; margin-right: auto; }
.brand b { font: 700 18px/1 var(--font-display); letter-spacing: -0.01em; }
.brand b i { font-style: normal; color: var(--accent); }
.brand span { color: var(--muted); font-size: 13px; }
.controls { display: flex; flex-wrap: wrap; gap: 10px; }
.seg { display: inline-flex; border: 1px solid var(--line); border-radius: 999px; padding: 2px; background: var(--surface-2); }
.seg button {
  border: 0; background: transparent; color: var(--muted); font: 500 12.5px/1 var(--font-body);
  padding: 7px 11px; border-radius: 999px; cursor: pointer; letter-spacing: 0.02em;
}
.seg button[aria-pressed="true"] { background: var(--surface); color: var(--fg); box-shadow: 0 1px 2px rgb(0 0 0 / 0.12); }
.seg button:hover:not([aria-pressed="true"]) { color: var(--fg); }

/* Search */
.search-band { padding-block: 28px 20px; }
.search-row { display: flex; gap: 10px; flex-wrap: wrap; }
.combo { position: relative; flex: 1 1 320px; min-width: 0; }
.combo input {
  width: 100%; font: 500 17px/1 var(--font-mono); padding: 14px 16px; color: var(--fg);
  background: var(--surface); border: 1.5px solid var(--line); border-radius: var(--radius);
}
.combo input:focus { border-color: var(--accent); outline: none; box-shadow: 0 0 0 3px var(--accent-soft); }
.combo input::placeholder { font-family: var(--font-body); font-weight: 400; color: var(--muted); }
select, .btn {
  font: 500 14px/1 var(--font-body); padding: 0 16px; min-height: 48px; border-radius: var(--radius);
  border: 1.5px solid var(--line); background: var(--surface); color: var(--fg); cursor: pointer;
}
.btn.primary { background: var(--accent); border-color: var(--accent); color: var(--bg); font-weight: 600; }
.btn.primary:hover { filter: brightness(1.08); }
.suggest {
  position: absolute; left: 0; right: 0; top: calc(100% + 6px); z-index: 20; margin: 0; padding: 4px;
  list-style: none; background: var(--surface); border: 1px solid var(--line); border-radius: var(--radius);
  box-shadow: 0 12px 30px rgb(0 0 0 / 0.14); max-height: 320px; overflow-y: auto;
}
.suggest li { display: flex; gap: 12px; align-items: baseline; padding: 9px 12px; border-radius: 7px; cursor: pointer; }
.suggest li[aria-selected="true"], .suggest li:hover { background: var(--accent-soft); }
.suggest .sym { font: italic 500 15px var(--font-mono); min-width: 7ch; }
.suggest .nm { color: var(--muted); font-size: 13.5px; min-width: 0; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.tries { display: flex; flex-wrap: wrap; align-items: center; gap: 8px; margin-top: 12px; color: var(--muted); font-size: 13.5px; }
.chip {
  font: italic 500 13px/1 var(--font-mono); padding: 6px 10px; border-radius: 999px; cursor: pointer;
  border: 1px solid var(--line); background: var(--surface); color: var(--fg);
}
.chip:hover { border-color: var(--accent); color: var(--accent); }
.note { color: var(--muted); font-size: 12.5px; margin-top: 10px; }

/* Dossier */
.dossier { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 16px; padding-bottom: 40px; }
.card { background: var(--surface); border: 1px solid var(--line); border-radius: var(--radius); padding: 20px 22px; min-width: 0; }
.card.full { grid-column: 1 / -1; }
.card h2 {
  margin: 0 0 14px; font: 500 11.5px/1.2 var(--font-body); text-transform: uppercase; letter-spacing: 0.12em;
  color: var(--muted); display: flex; justify-content: space-between; gap: 12px; align-items: baseline;
}
.card h2 a { text-transform: none; letter-spacing: 0; font-size: 12.5px; }
@media (max-width: 760px) { .dossier { grid-template-columns: minmax(0, 1fr); } }

/* Identity card */
.ident { display: grid; grid-template-columns: minmax(0, 1.25fr) minmax(0, 1fr); gap: 20px 32px; }
@media (max-width: 760px) { .ident { grid-template-columns: minmax(0, 1fr); } }
.symbol { font: italic 500 clamp(40px, 7vw, 64px)/1 var(--font-mono); letter-spacing: -0.02em; margin: 0; }
.fullname { font: 500 19px/1.3 var(--font-display); margin: 10px 0 4px; text-wrap: balance; }
.species-tag { color: var(--muted); font-size: 13.5px; }
.facts { display: grid; grid-template-columns: max-content minmax(0, 1fr); gap: 7px 16px; margin: 0; font-size: 14px; }
.facts dt { color: var(--muted); }
.facts dd { margin: 0; min-width: 0; overflow-wrap: anywhere; }
.mono { font-family: var(--font-mono); font-size: 13.5px; font-variant-numeric: tabular-nums; }
.pill { display: inline-block; padding: 2px 8px; border-radius: 999px; background: var(--accent-soft); color: var(--accent); font-size: 12.5px; font-weight: 500; }
.pill.warm { background: var(--warm-soft); color: var(--warm); }
.links { display: flex; flex-wrap: wrap; gap: 6px; }
.links a {
  font: 500 12.5px/1 var(--font-mono); padding: 6px 9px; border-radius: 6px; text-decoration: none;
  background: var(--surface-2); color: var(--fg); border: 1px solid var(--line);
}
.links a:hover { border-color: var(--accent); color: var(--accent); }
.ideo { margin-top: 18px; }
.ideo svg { width: 100%; height: auto; display: block; overflow: visible; }
.ideo .cap { font-size: 12.5px; color: var(--muted); margin-top: 4px; }

/* Plain-language box (student mode) */
.plain {
  margin-top: 14px; padding: 12px 14px; border-radius: 8px; background: var(--warm-soft); color: var(--fg);
  font-size: 14px; border-left: 3px solid var(--warm);
}
.plain b { display: block; font: 500 11px/1.2 var(--font-body); text-transform: uppercase; letter-spacing: 0.12em; color: var(--warm); margin-bottom: 4px; }
.plain p { margin: 0; }
.plain p + p { margin-top: 6px; }

.prose { margin: 0; max-width: 70ch; }
.prose + .prose { margin-top: 10px; }
.ref { font: 500 10.5px var(--font-mono); vertical-align: super; text-decoration: none; padding: 0 2px; }
.subhead { font-weight: 600; font-size: 13.5px; margin: 16px 0 6px; }
.tags { display: flex; flex-wrap: wrap; gap: 6px; }
.tags span { padding: 3px 9px; border-radius: 6px; background: var(--surface-2); font-size: 13px; }
.kv { display: flex; flex-wrap: wrap; gap: 6px 20px; font-size: 14px; margin-bottom: 12px; }
.kv span { color: var(--muted); }

/* Diseases */
.dis { list-style: none; margin: 0; padding: 0; display: grid; gap: 9px; }
.dis li { display: grid; grid-template-columns: minmax(0, 1fr) 46px; gap: 3px 10px; align-items: center; }
.dis a { color: var(--fg); text-decoration: none; font-size: 14px; overflow-wrap: anywhere; }
.dis a:hover { color: var(--accent); text-decoration: underline; }
.dis .sc { font: 500 12.5px var(--font-mono); text-align: right; color: var(--muted); font-variant-numeric: tabular-nums; }
.dis .track { grid-column: 1 / -1; height: 5px; background: var(--surface-2); border-radius: 3px; overflow: hidden; }
.dis .track i { display: block; height: 100%; background: var(--accent); border-radius: 3px; }
.meta { color: var(--muted); font-size: 12.5px; margin-top: 14px; display: flex; flex-wrap: wrap; justify-content: space-between; gap: 8px; }

/* Papers */
.papers { list-style: none; margin: 0; padding: 0; display: grid; gap: 0; }
.papers li { padding: 12px 0; border-top: 1px solid var(--line); display: grid; grid-template-columns: 92px minmax(0, 1fr); gap: 14px; }
.papers li:first-child { border-top: 0; padding-top: 0; }
.papers .date { font: 500 12.5px var(--font-mono); color: var(--muted); font-variant-numeric: tabular-nums; padding-top: 2px; }
.papers a.t { color: var(--fg); text-decoration: none; font-weight: 500; }
.papers a.t:hover { color: var(--accent); text-decoration: underline; }
.papers .au { color: var(--muted); font-size: 13px; margin-top: 2px; }
.papers .badges { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 5px; }
@media (max-width: 520px) { .papers li { grid-template-columns: minmax(0, 1fr); gap: 2px; } }

/* States */
.skel { display: grid; gap: 8px; }
.skel i { display: block; height: 12px; border-radius: 4px; background: linear-gradient(90deg, var(--surface-2), var(--line), var(--surface-2)); background-size: 200% 100%; animation: sh 1.3s linear infinite; }
.skel i:nth-child(2) { width: 85%; } .skel i:nth-child(3) { width: 65%; }
@keyframes sh { to { background-position: -200% 0; } }
@media (prefers-reduced-motion: reduce) { .skel i { animation: none; } }
.err { color: var(--danger); font-size: 14px; display: flex; flex-wrap: wrap; gap: 10px; align-items: center; }
.err button { font: 500 13px var(--font-body); padding: 6px 12px; border-radius: 6px; border: 1px solid currentColor; background: transparent; color: inherit; cursor: pointer; }
.empty { color: var(--muted); font-size: 14px; }
.banner { padding: 18px 22px; border-radius: var(--radius); border: 1px dashed var(--line); color: var(--muted); }

/* Tooltip */
.tip {
  position: fixed; z-index: 50; pointer-events: none; background: var(--fg); color: var(--bg);
  font-size: 12.5px; line-height: 1.4; padding: 6px 9px; border-radius: 6px; max-width: 280px;
  box-shadow: 0 6px 18px rgb(0 0 0 / 0.2); font-variant-numeric: tabular-nums;
}

/* Expression bars */
.expr { display: grid; gap: 2px; }
.expr .row { display: grid; grid-template-columns: minmax(0, 15rem) minmax(0, 1fr) 4.5rem; gap: 12px; align-items: center; font-size: 13px; padding: 3px 6px; border-radius: 5px; }
.expr .row:hover { background: var(--surface-2); }
.expr .nm { overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.expr .bar { height: 10px; }
.expr .bar i { display: block; height: 100%; background: var(--accent); border-radius: 0 4px 4px 0; min-width: 2px; }
.expr .v { text-align: right; font: 500 12.5px var(--font-mono); color: var(--muted); font-variant-numeric: tabular-nums; }
.expr .axis { display: flex; justify-content: space-between; color: var(--muted); font-size: 12px; padding: 4px 6px 0; }
@media (max-width: 560px) {
  .expr .row { grid-template-columns: minmax(0, 1fr) 4rem; gap: 2px 10px; }
  .expr .bar { grid-column: 1 / -1; grid-row: 2; }
}
.linkbtn { background: none; border: 0; color: var(--accent); cursor: pointer; font: 500 13px var(--font-body); padding: 10px 0 0; }

/* Network */
.net svg { width: 100%; max-width: 440px; display: block; margin: 0 auto; height: auto; }
.net .node { cursor: pointer; }
.net .node circle { transition: fill 0.15s; }
.net .node:hover circle, .net .node:focus-visible circle { fill: var(--accent-soft); stroke-width: 2.5; }
.net .node:focus { outline: none; }

/* 3D structure */
.mol { position: relative; width: 100%; height: 340px; border-radius: 8px; background: var(--surface-2); overflow: hidden; }
.mol .msg { position: absolute; inset: 0; display: grid; place-items: center; color: var(--muted); font-size: 13.5px; }
.molbar { display: flex; flex-wrap: wrap; gap: 10px; align-items: center; justify-content: space-between; margin-top: 10px; }
.molbar .btns { display: flex; gap: 6px; }
.legend { display: flex; flex-wrap: wrap; gap: 6px 14px; font-size: 12.5px; color: var(--muted); }
.legend span { display: inline-flex; align-items: center; gap: 6px; }
.legend i { width: 10px; height: 10px; border-radius: 3px; display: inline-block; flex: none; }
.legend b { color: var(--fg); font: 500 12.5px var(--font-mono); font-variant-numeric: tabular-nums; }
.small-btn { font: 500 12.5px var(--font-body); padding: 6px 10px; border-radius: 6px; border: 1px solid var(--line); background: var(--surface); color: var(--fg); cursor: pointer; }
.small-btn:hover, .small-btn[aria-pressed="true"] { border-color: var(--accent); color: var(--accent); }

/* ClinVar */
.stack { display: flex; gap: 2px; height: 16px; margin: 2px 0 12px; }
.stack i { display: block; height: 100%; min-width: 3px; }
.stack i:first-child { border-radius: 4px 0 0 4px; }
.stack i:last-child { border-radius: 0 4px 4px 0; }
.vars { list-style: none; margin: 0; padding: 0; }
.vars li { padding: 10px 0; border-top: 1px solid var(--line); display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 3px 12px; }
.vars li:first-child { border-top: 0; }
.vars a { color: var(--fg); text-decoration: none; font-family: var(--font-mono); font-size: 13.5px; overflow-wrap: anywhere; }
.vars a:hover { color: var(--accent); text-decoration: underline; }
.vars a b { font-weight: 500; color: var(--accent); }
.vars .stars { font-size: 13px; color: var(--warm); letter-spacing: 1px; white-space: nowrap; }
.vars .cond { grid-column: 1 / -1; color: var(--muted); font-size: 13px; }

/* Toolbar: compare + export */
.tools { display: flex; flex-wrap: wrap; gap: 10px 16px; align-items: center; justify-content: space-between; margin-bottom: 16px; }
.tools form { display: flex; gap: 8px; flex: 1 1 300px; max-width: 480px; min-width: 0; }
.tools input { flex: 1; min-width: 0; font: 500 14px var(--font-mono); padding: 9px 12px; border: 1.5px solid var(--line); border-radius: 8px; background: var(--surface); color: var(--fg); }
.tools input:focus { border-color: var(--accent); outline: none; }
.tools input::placeholder { font-family: var(--font-body); color: var(--muted); }
.tools .exp { display: flex; flex-wrap: wrap; gap: 8px; }
.btn:disabled { opacity: 0.55; cursor: default; filter: none; }
.btn.slim { min-height: 38px; font-size: 13px; padding: 0 12px; }

/* AI summary */
.ai-card { border-color: var(--accent); }
.ai-badge { font: 500 11px/1.4 var(--font-body); padding: 2px 8px; border-radius: 999px; background: var(--accent-soft); color: var(--accent); text-transform: none; letter-spacing: 0; }
.ai-out p { margin: 0 0 10px; max-width: 75ch; }
.ai-out ul { margin: 0 0 10px; padding-left: 20px; max-width: 75ch; }
.ai-out li + li { margin-top: 4px; }
.ai-note { color: var(--muted); font-size: 12.5px; margin: 10px 0 0; }
.trbar { display: flex; flex-wrap: wrap; gap: 8px 12px; align-items: center; margin-top: 10px; font-size: 12.5px; color: var(--muted); }
.trbar .err { font-size: 12.5px; }

/* Comparison */
.cmp-wrap { overflow-x: auto; }
.cmp { width: 100%; min-width: 520px; border-collapse: collapse; font-size: 13.5px; }
.cmp th, .cmp td { text-align: left; vertical-align: top; padding: 9px 10px; border-top: 1px solid var(--line); }
.cmp thead th { border-top: 0; font: italic 500 20px var(--font-mono); padding-bottom: 6px; }
.cmp tbody th { color: var(--muted); font-weight: 500; width: 22%; }
.cmp td { width: 39%; overflow-wrap: anywhere; }
.cmp ol { margin: 0; padding-left: 18px; }
.cmp .hl { color: var(--accent); font-weight: 600; }
.cmp .muted { color: var(--muted); }
.h-actions { display: inline-flex; gap: 12px; align-items: baseline; text-transform: none; letter-spacing: 0; }
.h-actions button { background: none; border: 0; padding: 0; color: var(--accent); cursor: pointer; font: 500 12.5px var(--font-body); }
.shared { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 8px; }
.shared button { font: 500 12.5px var(--font-mono); padding: 4px 9px; border-radius: 6px; border: 1px solid var(--line); background: var(--accent-soft); color: var(--fg); cursor: pointer; }
.shared button:hover { border-color: var(--accent); }

footer { border-top: 1px solid var(--line); color: var(--muted); font-size: 12.5px; }
footer .wrap { padding-block: 18px 28px; }

/* Print / PDF: light palette, no controls, no WebGL canvas. */
@media print {
  html:not(#p) {
    --bg: #fff; --surface: #fff; --surface-2: #f1f4f3; --fg: #111; --muted: #555; --line: #ccc;
    --accent: #0a7466; --accent-soft: #e3f1ee; --warm: #9a4f0b; --warm-soft: #fbf1e6;
    --cv-p: #a3261b; --cv-lp: #e2866a; --cv-vus: #c5cbc9; --cv-lb: #4fab99; --cv-b: #17675b; color-scheme: light;
  }
  .bar, .search-band, .tools, .linkbtn, .small-btn, .molbar .btns, .err button, .h-actions, .tip, .mol, .net + .note { display: none !important; }
  body { background: #fff; }
  .card { break-inside: avoid; }
  .dossier { gap: 10px; }
  a { color: inherit; text-decoration: none; }
}